Reactome | Protein hydroxylation

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Protein hydroxylation Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331805
displayName	Protein hydroxylation
eventOf	[Pathway:R-CFA-163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2545] protein hydroxylation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-9629946] JMJD4:Fe2+ hydroxylates a lysine residue of ETF1 - Canis familiaris [Reaction:R-CFA-9629888] KDM8:Fe2+ hydroxylates an arginine residue of RCCD1 - Canis familiaris [Reaction:R-CFA-9629869] KDM8:Fe2+ hydroxylates an arginine residue of RPS6 - Canis familiaris [Reaction:R-CFA-9630022] JMJD6 dimer hydroxylates lysine residues of U2AF2 - Canis familiaris [Reaction:R-CFA-9629591] JMJD7 dimer hydroxlates a lysine residue of DRG1 - Canis familiaris [Reaction:R-CFA-9629578] JMJD7 dimer hydroxlates a lysine residue of DRG2 - Canis familiaris [Reaction:R-CFA-9630769] OGFOD1:Fe2+ hydroxylates a proline residue of RPS23 - Canis familiaris [Reaction:R-CFA-9630993] RIOX1:Fe2+ hydroxylates a histidine residue of RPL8 - Canis familiaris [Reaction:R-CFA-9630967] RIOX2Fe2+ hydroxylates a histidine residue of RPL27A - Canis familiaris
inferredFrom	[Pathway:R-HSA-9629569] Protein hydroxylation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Protein hydroxylation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-9629569
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-163841] Gamma carboxylation, hypusinylation, hydroxylation, and arylsulfatase activation
(inferredTo)	[Pathway:R-HSA-9629569] Protein hydroxylation

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