Reactome | CDK1 phosphorylates RUNX2

Schema > Reaction > Entries

CDK1 phosphorylates RUNX2 Show undefined attributes

catalystActivity	[CatalystActivity:10239735] cyclin-dependent protein serine/threonine kinase activity of CCNB1:p-T161-CDK1 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10316196
displayName	CDK1 phosphorylates RUNX2
eventOf	[Pathway:R-CFA-8878166] Transcriptional regulation by RUNX2 - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9009282] CDK1 phosphorylates RUNX2 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-CFA-8865420] RUNX2:CBFB [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CDK1 phosphorylates RUNX2
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-CFA-9008410] p-S451-RUNX2:CBFB [nucleoplasm]
precedingEvent	[Reaction:R-CFA-170153] Dephosphorylation of nuclear Cyclin B1:phospho-Cdc2 (Thr 14, Tyr15) complexes by Cdc25 phosphatases - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-9009282
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8878166] Transcriptional regulation by RUNX2
(inferredTo)	[Reaction:R-HSA-9009282] CDK1 phosphorylates RUNX2