Reactome | BTK in PIP3:BTK:G beta-gamma complex is activated

Schema > Reaction > Entries

BTK in PIP3:BTK:G beta-gamma complex is activated Show undefined attributes

category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10315011
displayName	BTK in PIP3:BTK:G beta-gamma complex is activated
eventOf	[Pathway:R-CFA-8964315] G beta:gamma signalling through BTK - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-8964317] PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex - Canis familiaris
inferredFrom	[Reaction:R-HSA-8964271] BTK in PIP3:BTK:G beta-gamma complex is activated - Homo sapiens
input	[Complex:R-CFA-8964249] PIP3:BTK:G-protein beta-gamma complex [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	BTK in PIP3:BTK:G beta-gamma complex is activated
output	[Complex:R-CFA-8964249] PIP3:BTK:G-protein beta-gamma complex [plasma membrane]
precedingEvent	[Reaction:R-CFA-8964241] G beta-gamma complex and PIP3 recruit BTK to membrane - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-8964271
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8964315] G beta:gamma signalling through BTK
(precedingEvent)	[Reaction:R-CFA-8964317] PIP3:BTK:G beta-gamma complex dissociates to Active BTK, PIP3 and G beta-gamma complex
(inferredTo)	[Reaction:R-HSA-8964271] BTK in PIP3:BTK:G beta-gamma complex is activated

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