Reactome | AcM-UBE2M transfers NEDD8 to CUL9:RBX1

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AcM-UBE2M transfers NEDD8 to CUL9:RBX1 Show undefined attributes

catalystActivity	[CatalystActivity:10314801] NEDD8 transferase activity of NEDD8-AcM-UBE2M:CUL9:RBX1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10314803
displayName	AcM-UBE2M transfers NEDD8 to CUL9:RBX1
eventOf	[Pathway:R-CFA-8951664] Neddylation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-8956026] CUL9:RBX1 ubiquitinates BIRC5 - Canis familiaris [Reaction:R-CFA-8956050] NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1 - Canis familiaris
inferredFrom	[Reaction:R-HSA-8956025] AcM-UBE2M transfers NEDD8 to CUL9:RBX1 - Homo sapiens
input	[Complex:R-CFA-8955949] NEDD8-AcM-UBE2M:CUL9:RBX1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	AcM-UBE2M transfers NEDD8 to CUL9:RBX1
output	[Complex:R-CFA-8955941] NEDD8-CUL9:RBX1 [cytosol] [EntityWithAccessionedSequence:R-CFA-8951627] UBE2M [cytosol]
precedingEvent	[Reaction:R-CFA-8956031] NEDD8:AcM-UBE2M binds CUL9:RBX1 ubiquitin ligase complex - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-8956025
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8951664] Neddylation
(precedingEvent)	[Reaction:R-CFA-8956026] CUL9:RBX1 ubiquitinates BIRC5 [Reaction:R-CFA-8956050] NEDD8-CUL9:RBX1 binds CUL7:CCDC8:OBSL1
(inferredTo)	[Reaction:R-HSA-8956025] AcM-UBE2M transfers NEDD8 to CUL9:RBX1

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