Reactome | PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)

Schema > Reaction > Entries

PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) Show undefined attributes

catalystActivity	[CatalystActivity:10313215] metalloendopeptidase activity of Mitochondrial processing peptidase [mitochondrial matrix]
category	transition
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10313217
displayName	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)
eventOf	[Pathway:R-CFA-8949664] Processing of SMDT1 - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-8953461] SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex - Canis familiaris [BlackBoxEvent:R-CFA-8949659] AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU - Canis familiaris [Reaction:R-CFA-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix - Canis familiaris
inferredFrom	[Reaction:R-HSA-8949649] PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE) - Homo sapiens
input	[Complex:R-CFA-8949643] proSMDT1:C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)
output	[Complex:R-CFA-8949645] C2orf47:AFG3L2:SPG7:PHB:PHB2 [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-CFA-8949227] SMDT1 [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-CFA-8949642] SMDT1 [mitochondrial matrix]
precedingEvent	[Reaction:R-CFA-8949661] C2orf47:AFG3L2 binds the transit peptide of SMDT1 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-8949649
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8949664] Processing of SMDT1
(precedingEvent)	[Reaction:R-CFA-8953461] SMDT1 assists in assembling MCU, MCUB, MICU1, MICU2 (or MICU3) yielding the MCU complex [BlackBoxEvent:R-CFA-8949659] AFG3L2 (m-AAA protease) degrades SMDT1 that is not assembled in MCU [Reaction:R-CFA-8949178] MCU translocates calcium from the mitochondrial intermembrane space to the mitochondrial matrix
(inferredTo)	[Reaction:R-HSA-8949649] PMPCA:PMPCB cleaves the transit peptide of proSMDT1 (proEMRE)