Reactome | RNF144A polyubiquitinates PRKDC

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RNF144A polyubiquitinates PRKDC Show undefined attributes

catalystActivity	[CatalystActivity:10311892] ubiquitin protein ligase activity of RNF144A:PRKDC:Ub:UBE2L3 [cytosol]
category	omitted
compartment	[Compartment:70101] cytosol [Compartment:74700] endosome membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10311894
displayName	RNF144A polyubiquitinates PRKDC
eventOf	[Pathway:R-CFA-8866654] E3 ubiquitin ligases ubiquitinate target proteins - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-8938773] RNF144A polyubiquitinates PRKDC - Homo sapiens
input	[Complex:R-CFA-8938767] RNF144A:PRKDC:Ub:UBE2L3 [cytosol] 2 × [Complex:R-CFA-8938763] Ub:UBE2L3 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	RNF144A polyubiquitinates PRKDC
output	[EntityWithAccessionedSequence:R-CFA-8938766] PRKDC [cytosol] [EntityWithAccessionedSequence:R-CFA-8938771] RNF144A [endosome membrane] 3 × [EntityWithAccessionedSequence:R-CFA-947631] UBE2L3 [cytosol]
precedingEvent	[Reaction:R-CFA-8938770] RNF144A binds PRKDC and Ubiquitin:UBE2L3 - Canis familiaris
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-8938773
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8866654] E3 ubiquitin ligases ubiquitinate target proteins
(inferredTo)	[BlackBoxEvent:R-HSA-8938773] RNF144A polyubiquitinates PRKDC