Reactome | Release of STAT1 dimer from active receptor unit

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Release of STAT1 dimer from active receptor unit Show undefined attributes

category	dissociation
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10260741
displayName	Release of STAT1 dimer from active receptor unit
eventOf	[Pathway:R-CFA-877300] Interferon gamma signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CFA-873917] Translocation of STAT1 dimer to nucleus - Canis familiaris
inferredFrom	[Reaction:R-HSA-873927] Release of STAT1 dimer from active receptor unit - Homo sapiens
input	[Complex:R-CFA-909556] p-STAT1 dimer bound to p-IFNGR1 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Release of STAT1 dimer from active receptor unit
output	[Complex:R-CFA-873827] IFNG-activated factor (GAF) [cytosol] [Complex:R-CFA-873814] IFNG:p-IFNGR1:p-JAK1:IFNGR2:p-JAK2 [plasma membrane]
precedingEvent	[Reaction:R-CFA-909552] Phosphorylation of STAT1 at Ser727 - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-873927
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-877300] Interferon gamma signaling
(precedingEvent)	[BlackBoxEvent:R-CFA-873917] Translocation of STAT1 dimer to nucleus
(inferredTo)	[Reaction:R-HSA-873927] Release of STAT1 dimer from active receptor unit

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