Reactome | FasL/ CD95L signaling

Schema > Pathway > Entries

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10328691
displayName	FasL/ CD95L signaling
eventOf	[Pathway:R-CFA-73887] Death Receptor Signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:2133497] apoptotic signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CFA-75244] FASL binds FAS Receptor - Canis familiaris [Reaction:R-CFA-71050] Trimerization of the FASL:FAS receptor complex - Canis familiaris
inferredFrom	[Pathway:R-HSA-75157] FasL/ CD95L signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	FasL/ CD95L signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-75157
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEncapsulatedEvent)	[Pathway:R-CFA-5357769] Caspase activation via extrinsic apoptotic signalling pathway [Pathway:R-CFA-5633008] TP53 Regulates Transcription of Cell Death Genes
(hasEvent)	[Pathway:R-CFA-73887] Death Receptor Signaling
(inferredTo)	[Pathway:R-HSA-75157] FasL/ CD95L signaling

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