Reactome | Tryptophan catabolism

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Tryptophan catabolism Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10328703
displayName	Tryptophan catabolism
eventOf	[Pathway:R-CFA-71291] Metabolism of amino acids and derivatives - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:10735] L-tryptophan catabolic process
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CFA-352232] SLC7A5:SLC3A2 transports neutral amino acids from extracellular region to cytosol - Canis familiaris [Reaction:R-CFA-8870352] SLC36A4 transports L-Trp from extracellular region to cytosol - Canis familiaris [Reaction:R-CFA-71188] TDO tetramer dioxygenates L-Trp to NFK - Canis familiaris [Reaction:R-CFA-198563] IDO1 dioxygenates L-Trp to NFK - Canis familiaris [Reaction:R-CFA-888614] IDO2 dioxygenates L-Trp to NFK - Canis familiaris [Reaction:R-CFA-893596] PXLP-KYAT1 dimer transaminates L-KYN to KYNA - Canis familiaris [Reaction:R-CFA-71200] kynurenine + O2 + NADPH + H+ => 3-hydroxykynurenine + NADP+ + H2O - Canis familiaris [Reaction:R-CFA-9972889] AADAT transaminates 3HKYN to xanthurenate - Canis familiaris [Reaction:R-CFA-71217] 3-hydroxykynurenine + H2O => 3-hydroxyanthranilate + alanine + H+ - Canis familiaris [Reaction:R-CFA-71218] 3-hydroxyanthranilate + O2 => 2-amino-3-carboxymuconate semialdehyde - Canis familiaris [Reaction:R-CFA-893583] kynurenine + 2-oxoglutarate => 4-(2-aminophenyl)-2,4-dioxobutanoic acid + glutamate - Canis familiaris
inferredFrom	[Pathway:R-HSA-71240] Tryptophan catabolism - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Tryptophan catabolism
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-71240
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-71291] Metabolism of amino acids and derivatives
(inferredTo)	[Pathway:R-HSA-71240] Tryptophan catabolism
(hasEncapsulatedEvent)	[Pathway:R-CFA-196807] Nicotinate metabolism

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