Reactome | PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr

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PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr Show undefined attributes

catalystActivity	[CatalystActivity:10228486] phenylalanine 4-monooxygenase activity of PAH:Fe2+ tetramer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10228488
displayName	PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr
eventOf	[Pathway:R-CFA-8964208] Phenylalanine metabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-71155] TAT deaminates tyrosine - Canis familiaris
inferredFrom	[Reaction:R-HSA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Homo sapiens
input	[SimpleEntity:R-ALL-29870] BH4 [cytosol] [SimpleEntity:R-ALL-29502] L-Phe [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr (6R)-L-erythro-5,6,7,8-tetrahydrobiopterin + L-phenylalanine + O2 => (4aS,6R)-4a-hydroxy-L-erythro-5,6,7,8-tetrahydrobiopterin + L-tyrosine phenylalanine + tetrahydrobiopterin + O2 => tyrosine + 4a-hydroxytetrahydrobiopterin + H2O
output	[SimpleEntity:R-ALL-71112] 4aOH-BH4 [cytosol] [SimpleEntity:R-ALL-29506] L-Tyr [cytosol]
precedingEvent	[Reaction:R-CFA-71130] q-dihydrobiopterin + NADH + H+ => tetrahydrobiopterin + NAD+ - Canis familiaris [Reaction:R-CFA-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-71118
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-CFA-71155] TAT deaminates tyrosine
(hasEvent)	[Pathway:R-CFA-8964208] Phenylalanine metabolism
(inferredTo)	[Reaction:R-HSA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr

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