Reactome | L-Phe [cytosol]

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L-Phe [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
consumedByEvent	[Reaction:R-RNO-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Rattus norvegicus [Reaction:R-HSA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Homo sapiens [Reaction:R-MMU-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Mus musculus [Reaction:R-BTA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Bos taurus [Reaction:R-SSC-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Sus scrofa [Reaction:R-DRE-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Danio rerio [Reaction:R-XTR-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Xenopus tropicalis [Reaction:R-DME-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Drosophila melanogaster [Reaction:R-CEL-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Caenorhabditis elegans [Reaction:R-DDI-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Dictyostelium discoideum [Reaction:R-CFA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Canis familiaris [Reaction:R-GGA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr - Gallus gallus [Reaction:R-RNO-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Rattus norvegicus [Reaction:R-HSA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Homo sapiens [Reaction:R-MMU-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Mus musculus [Reaction:R-CFA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Canis familiaris [Reaction:R-BTA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Bos taurus [Reaction:R-SSC-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Sus scrofa [Reaction:R-DRE-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Danio rerio [Reaction:R-XTR-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Xenopus tropicalis [Reaction:R-GGA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Gallus gallus [Reaction:R-DME-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Drosophila melanogaster [Reaction:R-CEL-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Caenorhabditis elegans [Reaction:R-DDI-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Dictyostelium discoideum [Reaction:R-SPO-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Schizosaccharomyces pombe [Reaction:R-SCE-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine - Saccharomyces cerevisiae [FailedReaction:R-HSA-5649483] Defective PAH does not hydroxylate L-Phe to L-Tyr - Homo sapiens [Reaction:R-HSA-379848] phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate - Homo sapiens
crossReference	[DatabaseIdentifier:29503] COMPOUND:C00079
dbId	29502
displayName	L-Phe [cytosol]
inDisease	false
maxDepth	1
memberOf	[DefinedSet:R-ALL-352139] ligands of SLC16A10 [cytosol] [DefinedSet:R-ALL-352114] ligands of SLC43A1,2 [cytosol] [DefinedSet:R-ALL-352227] ligands of SLC7A5 [cytosol] [DefinedSet:R-ALL-375481] neutral amino acids [cytosol] [DefinedSet:R-ALL-352190] ligands of SLC7A8 [cytosol]
modified	[InstanceEdit:9619952] Wu, G, 2018-09-19
name	L-Phe (S)-alpha-amino-beta-phenylpropionic acid L-phenylalanine zwitterion L-phenylalanine
negativelyRegulates	[NegativeRegulation:R-HSA-2160520] Negative regulation by 'L-Phe [cytosol]'
positivelyRegulates	[PositiveRegulation:R-HSA-1474173] Positive regulation by 'L-Phe [cytosol]'
producedByEvent	[Reaction:R-RNO-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH - Rattus norvegicus [Reaction:R-HSA-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH - Homo sapiens [Reaction:R-MMU-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH - Mus musculus [Reaction:R-CFA-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH - Canis familiaris [Reaction:R-BTA-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH - Bos taurus [Reaction:R-SSC-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH - Sus scrofa [Reaction:R-DRE-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH - Danio rerio [Reaction:R-GGA-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH - Gallus gallus [Reaction:R-DME-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH - Drosophila melanogaster
referenceEntity	[ReferenceMolecule:chebi:58095] L-phenylalanine zwitterion [ChEBI:58095]
referenceType	ReferenceMolecule
schemaClass	SimpleEntity
stId	R-ALL-29502
updateTrackers	[UpdateTracker:9890502] Update Tracker - [SimpleEntity:29502] L-Phe [cytosol] - v52:[modifyName] [UpdateTracker:9895161] Update Tracker - [SimpleEntity:29502] L-Phe [cytosol] - v59:[addName, add_removeReferenceEntity] [UpdateTracker:9870587] Update Tracker - [SimpleEntity:29502] L-Phe [cytosol] - v38:[addName]

Referrals

(input)	[Reaction:R-RNO-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Reaction:R-HSA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Reaction:R-MMU-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Reaction:R-BTA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Reaction:R-SSC-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Reaction:R-DRE-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Reaction:R-XTR-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Reaction:R-DME-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Reaction:R-CEL-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Reaction:R-DDI-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Reaction:R-CFA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Reaction:R-GGA-71118] PAH:Fe2+ tetramer hydroxylates L-Phe to L-Tyr [Reaction:R-RNO-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-HSA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-MMU-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-CFA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-BTA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-SSC-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-DRE-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-XTR-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-GGA-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-DME-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-CEL-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-DDI-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-SPO-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [Reaction:R-SCE-893593] phenylalanine + pyruvate => keto-phenylpyruvate + alanine [FailedReaction:R-HSA-5649483] Defective PAH does not hydroxylate L-Phe to L-Tyr [Reaction:R-HSA-379848] phenylalanine + tRNA(Phe) + ATP => Phe-tRNA(Phe) + AMP + pyrophosphate
(output)	[Reaction:R-RNO-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH [Reaction:R-HSA-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH [Reaction:R-MMU-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH [Reaction:R-CFA-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH [Reaction:R-BTA-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH [Reaction:R-SSC-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH [Reaction:R-DRE-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH [Reaction:R-GGA-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH [Reaction:R-DME-5696365] ASRGL1 hydrolyses aspartame to L-Asp, L-Phe, MeOH
(hasMember)	[DefinedSet:R-ALL-352227] ligands of SLC7A5 [cytosol] [DefinedSet:R-ALL-352114] ligands of SLC43A1,2 [cytosol] [DefinedSet:R-ALL-352190] ligands of SLC7A8 [cytosol] [DefinedSet:R-ALL-375481] neutral amino acids [cytosol] [DefinedSet:R-ALL-352139] ligands of SLC16A10 [cytosol]
(regulator)	[PositiveRegulation:R-HSA-1474173] Positive regulation by 'L-Phe [cytosol]' [NegativeRegulation:R-HSA-2160520] Negative regulation by 'L-Phe [cytosol]'
(updatedInstance)	[UpdateTracker:9890502] Update Tracker - [SimpleEntity:29502] L-Phe [cytosol] - v52:[modifyName] [UpdateTracker:9895161] Update Tracker - [SimpleEntity:29502] L-Phe [cytosol] - v59:[addName, add_removeReferenceEntity] [UpdateTracker:9870587] Update Tracker - [SimpleEntity:29502] L-Phe [cytosol] - v38:[addName]

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