Reactome | beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA

Schema > Reaction > Entries

beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA Show undefined attributes

catalystActivity	[CatalystActivity:10228225] 3-hydroxyisobutyryl-CoA hydrolase activity of HIBCH [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10228227
displayName	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA
eventOf	[Pathway:R-CFA-70895] Branched-chain amino acid catabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+ - Canis familiaris
inferredFrom	[Reaction:R-HSA-70881] beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA - Homo sapiens
input	[SimpleEntity:R-ALL-71847] bHIB-CoA [mitochondrial matrix] [SimpleEntity:R-ALL-113521] H2O [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA (S)-3-hydroxyisobutanoyl-CoA + H2O => (S)-3-hydroxy-2-methylpropanoate + CoA + H(+)
output	[SimpleEntity:R-ALL-573404] bHIBA [mitochondrial matrix] [SimpleEntity:R-ALL-29374] CoA-SH [mitochondrial matrix] [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
precedingEvent	[Reaction:R-CFA-70870] ECHS1 hydrates methacrylyl-CoA - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-70881
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-70895] Branched-chain amino acid catabolism
(precedingEvent)	[Reaction:R-CFA-70885] beta-hydroxyisobutyrate + NAD+ <=> methylmalonyl semialdehyde + NADH + H+
(inferredTo)	[Reaction:R-HSA-70881] beta-hydroxyisobutyryl-CoA + H2O => beta-hydroxyisobutyrate + CoA

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