Reactome | Dimerization of procaspase-8

Schema > Pathway > Entries

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10328793
displayName	Dimerization of procaspase-8
eventOf	[Pathway:R-CFA-140534] Caspase activation via Death Receptors in the presence of ligand - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:423068] positive regulation of endopeptidase activity
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-73945] FAS-mediated dimerization of procaspase-8 - Canis familiaris [Reaction:R-CFA-141159] TNF-mediated dimerization of procaspase-8 - Canis familiaris
inferredFrom	[Pathway:R-HSA-69416] Dimerization of procaspase-8 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Dimerization of procaspase-8
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-69416
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-140534] Caspase activation via Death Receptors in the presence of ligand
(inferredTo)	[Pathway:R-HSA-69416] Dimerization of procaspase-8

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