Reactome | TNF-mediated dimerization of procaspase-8

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TNF-mediated dimerization of procaspase-8 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10235762
displayName	TNF-mediated dimerization of procaspase-8
eventOf	[Pathway:R-CFA-69416] Dimerization of procaspase-8 - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-141159] TNF-mediated dimerization of procaspase-8 - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-57031] CASP8 [cytosol] [Complex:R-CFA-140976] TRADD:TRAF2:RIP1:FADD:CASP8(1-479) [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	TNF-mediated dimerization of procaspase-8
output	[Complex:R-CFA-2671812] TRAF2:TRADD:RIP1:FADD:2xCASP8(1-479) [cytosol]
regulatedBy	[NegativeRegulation:10230627] Negative regulation by 'FLIP(S) [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-141159
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-69416] Dimerization of procaspase-8
(inferredTo)	[Reaction:R-HSA-141159] TNF-mediated dimerization of procaspase-8

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