Reactome | Regulation of TP53 Activity through Phosphorylation

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Regulation of TP53 Activity through Phosphorylation Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10328591
displayName	Regulation of TP53 Activity through Phosphorylation
eventOf	[Pathway:R-CFA-5633007] Regulation of TP53 Activity - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:3132571] regulation of signal transduction by p53 class mediator
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CFA-5693609] ATM phosphorylates TP53 at S15 - Canis familiaris [Reaction:R-CFA-6799332] ATR phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-69685] CHEK2 phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6799246] CHEK1 phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6798372] ATM phosphorylates DYRK2 - Canis familiaris [Reaction:R-CFA-6798374] DYRK2 phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6798373] MDM2 ubiquitinates DYRK2 - Canis familiaris [Reaction:R-CFA-3215251] TP53INP1 and HIPK2 bind TP53 - Canis familiaris [Reaction:R-CFA-6799409] HIPK2 phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6799431] TP53 binds HIPK1 - Canis familiaris [Reaction:R-CFA-6805035] TP53 binds STK11 and NUAK1 - Canis familiaris [Reaction:R-CFA-3222006] STK11 (LKB1) phosphorylates NUAK1 - Canis familiaris [Reaction:R-CFA-3222020] NUAK1 phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6805061] CK2 binds FACT - Canis familiaris [Reaction:R-CFA-6805059] CK2:FACT phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6805103] AURKA phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6805109] CDK2 phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-3222128] NOC2L binds TP53 - Canis familiaris [Reaction:R-CFA-6805122] AURKB binds TP53 - Canis familiaris [Reaction:R-CFA-6805126] AURKB phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6805276] CDK5 phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6805285] PLK3 phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6805399] TAF1 phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6805470] AMPK phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6805479] TP53RK phosphorylates TP53 - Canis familiaris
inferredFrom	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of TP53 Activity through Phosphorylation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-6804756
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEncapsulatedEvent)	[Pathway:R-CFA-6804759] Regulation of TP53 Activity through Association with Co-factors [Pathway:R-CFA-6806003] Regulation of TP53 Expression and Degradation
(hasEvent)	[Pathway:R-CFA-5633007] Regulation of TP53 Activity
(inferredTo)	[Pathway:R-HSA-6804756] Regulation of TP53 Activity through Phosphorylation

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