Reactome | XK:KEL:Zn2+ cleaves EDN3

Schema > Reaction > Entries

XK:KEL:Zn2+ cleaves EDN3 Show undefined attributes

catalystActivity	[CatalystActivity:10296811] metalloendopeptidase activity of XK:KEL:Zn2+ [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10296813
displayName	XK:KEL:Zn2+ cleaves EDN3
eventOf	[Pathway:R-CFA-375276] Peptide ligand-binding receptors - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-388560] EDNRA,EDNRB bind EDNs - Canis familiaris [Reaction:R-CFA-9731924] EDNRA binds EDNs - Canis familiaris
inferredFrom	[Reaction:R-HSA-5694082] XK:KEL:Zn2+ cleaves EDN3 - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-5694133] EDN3 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	XK:KEL:Zn2+ cleaves EDN3
output	[EntityWithAccessionedSequence:R-CFA-5694067] EDN3 [extracellular region] [EntityWithAccessionedSequence:R-CFA-388543] EDN3 [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-5694082
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-375276] Peptide ligand-binding receptors
(precedingEvent)	[Reaction:R-CFA-388560] EDNRA,EDNRB bind EDNs [Reaction:R-CFA-9731924] EDNRA binds EDNs
(inferredTo)	[Reaction:R-HSA-5694082] XK:KEL:Zn2+ cleaves EDN3