Reactome | phospho-ATM [nucleoplasm]

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phospho-ATM [nucleoplasm] Show undefined attributes

catalystActivities	[CatalystActivity:10248429] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-CFA-9006829] Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] - Canis familiaris [Complex:R-CFA-5686614] DNA DSB with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] - Canis familiaris [Complex:R-CFA-9980018] p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] - Canis familiaris [Complex:R-CFA-5686226] Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10227429
displayName	phospho-ATM [nucleoplasm]
endCoordinate	3056
hasModifiedResidue	[ModifiedResidue:10227426] O-phospho-L-serine at 1981 (in Homo sapiens) [ModifiedResidue:10227427] N6-acetyl-L-lysine at 3016 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-5693527] p-S1981,Ac-K3016-ATM [nucleoplasm] - Homo sapiens
maxDepth	1
name	phospho-ATM p-S1981,Ac-K3016-ATM A0A8I3RRE6
negativelyRegulates	[NegativeRegulation:10303725] Negative regulation by 'p-S1981,Ac-K3016-ATM [nucleoplasm]'
producedByEvent	[Reaction:R-CFA-5682026] MRN bound to shortened telomeres activates ATM - Canis familiaris [Reaction:R-CFA-5693540] MRN activates ATM - Canis familiaris [BlackBoxEvent:R-CFA-5686663] Completion of SSA - Canis familiaris
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8I3RRE6] UniProt:A0A8I3RRE6
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49646] Canis familiaris
stId	R-CFA-5693527
startCoordinate	1

Referrals

(activeUnit)	[CatalystActivity:10294688] protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:RIF1:PAX1IP:DCLRE1C [nucleoplasm] [CatalystActivity:10294112] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S327,T847-RBBP8:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [CatalystActivity:10227613] protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:p-4S,2T-BRCA1-A complex:CHEK2 [nucleoplasm] [CatalystActivity:10296600] protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:p-S25,S1778-TP53BP1:BRCA1-A complex [nucleoplasm] [CatalystActivity:10293922] protein serine/threonine kinase activity of DNA DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:K63PolyUb-K14,K16,p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:p-S102-WHSC1:RNF8:Zn2+:SUMO1:p-T4827-HERC2:UBE2N:UBE2V2:RNF168:PIAS4:TP53BP1 [nucleoplasm] [CatalystActivity:10293774] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX,Me2K21-HIST1H4A-Nucleosome:p-5T-MDC1:KDM4A,B:p-S102-WHSC1:RNF8:Zn2+:HERC2:PIAS4 [nucleoplasm] [CatalystActivity:10293881] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:p-5T-MDC1:WHSC1 [nucleoplasm] [CatalystActivity:10296583] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139-H2AFX-Nucleosome:MDC1 [nucleoplasm] [CatalystActivity:10294030] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:p-S139,Y142-H2AFX-Nucleosome [nucleoplasm] [CatalystActivity:10296597] protein serine/threonine kinase activity of DNA DSBs:p-MRN:p-S-1981,Ac-K3016-ATM:KAT5:p-Y142-H2AFX-Nucleosome [nucleoplasm] [CatalystActivity:10296655] protein serine/threonine kinase activity of DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]
(output)	[BlackBoxEvent:R-CFA-5686663] Completion of SSA [Reaction:R-CFA-5682026] MRN bound to shortened telomeres activates ATM [Reaction:R-CFA-5693540] MRN activates ATM
(regulator)	[NegativeRegulation:10303725] Negative regulation by 'p-S1981,Ac-K3016-ATM [nucleoplasm]'
(hasComponent)	[Complex:R-CFA-9006829] Shortened telomere:MRN:KAT5:p-S1981,Ac-K3016-ATM [nucleoplasm] [Complex:R-CFA-9980018] p-RPA:SSB-dsDNA with inter-SSA deletion:Flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:BRCA1-C complex [nucleoplasm] [Complex:R-CFA-5686614] DNA DSB with annealed 3' ssDNA overhangs and displaced flaps:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [Complex:R-CFA-5685987] 3' short overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [Complex:R-CFA-5686226] Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] [Complex:R-CFA-5686487] Cleaved Holliday Junction:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] [Complex:R-CFA-5685658] D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] [Complex:R-CFA-5686227] Extended D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-S990,Ac-K1249-BRIP1:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:SEM1:p-T309-RAD51:RAD51AP1 [nucleoplasm] [Complex:R-CFA-5686428] Cleaved D-Loop:p-MRN:p-S1981,Ac-K3016-ATM:KAT5:EXO1,DNA2:BLM,WRN:p-BRCA1-C complex:PALB2:p-T3387-BRCA2:p-T309-RAD51:RAD51AP1 [nucleoplasm] [Complex:R-CFA-5682162] DNA DSB:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [Complex:R-CFA-5682055] DNA DSBs:MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm] [Complex:R-CFA-5684122] 3' overhanging ssDNA-DSBs:p-MRN:p-S1981,Ac-K3016-ATM:KAT5 [nucleoplasm]
(physicalEntity)	[CatalystActivity:10248429] protein serine/threonine kinase activity of p-S1981,Ac-K3016-ATM [nucleoplasm]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-5693527] p-S1981,Ac-K3016-ATM [nucleoplasm]

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