Reactome | TNFR2 non-canonical NF-kB pathway

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TNFR2 non-canonical NF-kB pathway Show undefined attributes

compartment	[Compartment:876] plasma membrane [Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329817
displayName	TNFR2 non-canonical NF-kB pathway
eventOf	[Pathway:R-CFA-1280215] Cytokine Signaling in Immune system - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:261164] tumor necrosis factor-mediated signaling pathway
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-CFA-5668543] TRAF3:NIK binds TRAF2:cIAP1/2 - Canis familiaris [BlackBoxEvent:R-CFA-5668534] cIAP1,2 ubiquitinates NIK in cIAP1,2:TRAF2::TRAF3:NIK - Canis familiaris [BlackBoxEvent:R-CFA-5668520] 26Sproteasome degrades K48polyUb-NIK - Canis familiaris [Reaction:R-CFA-9714959] TNF-alpha inhibitors bind to TNF(1-233) trimer - Canis familiaris [Reaction:R-CFA-5668404] TNFA binds TNFR2 - Canis familiaris [Reaction:R-CFA-5668467] 2xTNFR2 binds TNFA trimer:TNFR2 - Canis familiaris [Reaction:R-CFA-5668417] cIAP1,2:TRAF2:TRAF3:NIK complex binds TNFR2 trimer - Canis familiaris [Pathway:R-CFA-5676594] TNF receptor superfamily (TNFSF) members mediating non-canonical NF-kB pathway - Canis familiaris [BlackBoxEvent:R-CFA-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK - Canis familiaris [BlackBoxEvent:R-CFA-5668454] K63polyUb-cIAP1,2 ubiquitinates TRAF3 - Canis familiaris [BlackBoxEvent:R-CFA-5668481] Protesomal degradation of K48polyUb-TRAF3 - Canis familiaris [Pathway:R-CFA-5676590] NIK-->noncanonical NF-kB signaling - Canis familiaris [Pathway:R-CFA-5669034] TNFs bind their physiological receptors - Canis familiaris
inferredFrom	[Pathway:R-HSA-5668541] TNFR2 non-canonical NF-kB pathway - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	TNFR2 non-canonical NF-kB pathway TNFRSF mediated non-canonical NF-kB pathway
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-5668541
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1280215] Cytokine Signaling in Immune system
(inferredTo)	[Pathway:R-HSA-5668541] TNFR2 non-canonical NF-kB pathway