Reactome | K63polyUb-cIAP1,2 ubiquitinates TRAF3

Schema > BlackBoxEvent > Entries

K63polyUb-cIAP1,2 ubiquitinates TRAF3 Show undefined attributes

catalystActivity	[CatalystActivity:10292516] ubiquitin-protein transferase activity of TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]
category	omitted
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10292518
displayName	K63polyUb-cIAP1,2 ubiquitinates TRAF3
eventOf	[Pathway:R-CFA-5668541] TNFR2 non-canonical NF-kB pathway - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CFA-5668481] Protesomal degradation of K48polyUb-TRAF3 - Canis familiaris
inferredFrom	[BlackBoxEvent:R-HSA-5668454] K63polyUb-cIAP1,2 ubiquitinates TRAF3 - Homo sapiens
input	[Polymer:R-CFA-912740] K48polyUb [cytosol] [Complex:R-CFA-5668433] TNFSF:TNFRSF heterotrimer:K63polyUb-cIAP1,2:TRAF2:TRAF3:NIK [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	K63polyUb-cIAP1,2 ubiquitinates TRAF3
output	[Complex:R-CFA-5668442] TNFSF:TNFRSF heterotrimer:TRAF2:K63polyUb-cIAP1,2:K48polyUb-TRAF3:NIK [plasma membrane]
precedingEvent	[BlackBoxEvent:R-CFA-5668414] TRAF2 ubiquitinates cIAP1,2 in cIAP1,2:TRAF1:TRAF2:TRAF3:NIK - Canis familiaris
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:49646] Canis familiaris
stId	R-CFA-5668454
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-5668541] TNFR2 non-canonical NF-kB pathway
(precedingEvent)	[BlackBoxEvent:R-CFA-5668481] Protesomal degradation of K48polyUb-TRAF3
(inferredTo)	[BlackBoxEvent:R-HSA-5668454] K63polyUb-cIAP1,2 ubiquitinates TRAF3