Reactome | phospho-SPHK1 [cytosol]

Schema > EntityWithAccessionedSequence > Entries

catalystActivities	[CatalystActivity:10286602] sphingosine kinase activity of p-S225-SPHK1 [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-CFA-9836608] EIF2AK2:p-SPHK1 [cytosol] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-9836606] SPHK1 binds PKR - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10286546
displayName	phospho-SPHK1 [cytosol]
endCoordinate	384
hasModifiedResidue	[ModifiedResidue:10286544] O-phospho-L-serine at 225 (in Homo sapiens)
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-5218716] p-S225-SPHK1 [cytosol] - Homo sapiens
maxDepth	1
name	phospho-SPHK1 p-S225-SPHK1 A0A8I3S0D0
producedByEvent	[Reaction:R-CFA-5218823] PKC phosphorylates sphingosine kinase 1 - Canis familiaris [BlackBoxEvent:R-CFA-9836621] p-S225-SPHK1 localizes to cytosol - Canis familiaris
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8I3S0D0] UniProt:A0A8I3S0D0
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49646] Canis familiaris
stId	R-CFA-5218716
startCoordinate	1

(physicalEntity)	[CatalystActivity:10286602] sphingosine kinase activity of p-S225-SPHK1 [cytosol]
(input)	[Reaction:R-CFA-9836606] SPHK1 binds PKR
(output)	[Reaction:R-CFA-5218823] PKC phosphorylates sphingosine kinase 1 [BlackBoxEvent:R-CFA-9836621] p-S225-SPHK1 localizes to cytosol
(hasComponent)	[Complex:R-CFA-9836608] EIF2AK2:p-SPHK1 [cytosol]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-5218716] p-S225-SPHK1 [cytosol]

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