Reactome | IDH2 dimer decarboxylates isocitrate

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IDH2 dimer decarboxylates isocitrate Show undefined attributes

catalystActivity	[CatalystActivity:10131913] isocitrate dehydrogenase (NADP+) activity of IDH2 dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10098795] Wright, Adam, 2024-03-07
dbId	10131920
displayName	IDH2 dimer decarboxylates isocitrate
eventOf	[Pathway:R-CFA-71403] Citric acid cycle (TCA cycle) - Canis familiaris
evidenceType	[EvidenceType:9864366] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-450971] NNT dimer transfers proton from NADPH to NAD+ - Canis familiaris [Reaction:R-CFA-1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) - Canis familiaris [Reaction:R-CFA-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) - Canis familiaris [Reaction:R-CFA-1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria) - Canis familiaris [Reaction:R-CFA-1237047] CA4:Zn2+ hydrates CO2 to HCO3- - Canis familiaris [Reaction:R-CFA-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol - Canis familiaris [Reaction:R-CFA-1237069] RHAG transports CO2 from extracellular region to cytosol - Canis familiaris
inferredFrom	[Reaction:R-HSA-450984] IDH2 dimer decarboxylates isocitrate - Homo sapiens
input	[SimpleEntity:R-ALL-29938] ISCIT [mitochondrial matrix] [SimpleEntity:R-ALL-113563] NADP+ [mitochondrial matrix]
isInDisease	false
isInferred	true
name	IDH2 dimer decarboxylates isocitrate D-threo-isocitrate + NADP(+) => 2-oxoglutarate + CO2 + NADPH
output	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-29376] CO2 [mitochondrial matrix] [SimpleEntity:R-ALL-113600] NADPH [mitochondrial matrix]
precedingEvent	[Reaction:R-CFA-70971] ACO2 isomerizes citrate - Canis familiaris
regulatedBy	[NegativeRegulation:10131921] Negative regulation by 'AcK-IDH2 dimer [mitochondrial matrix]'
releaseDate	2024-03-27
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-450984
summation	[Summation:9864365] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-CFA-1475025] Carbonic anhydrase hydrates carbon dioxide (plasma membrane) [Reaction:R-CFA-1475026] Carbonic anhydrase hydrates carbon dioxide (cytosol) [Reaction:R-CFA-1475032] Carbonic anhydrase hydrates carbon dioxide (mitochondria) [Reaction:R-CFA-1237047] CA4:Zn2+ hydrates CO2 to HCO3- [Reaction:R-CFA-1237042] AQP1 tetramer transports CO2 from extracellular region to cytosol [Reaction:R-CFA-1237069] RHAG transports CO2 from extracellular region to cytosol [Reaction:R-CFA-450971] NNT dimer transfers proton from NADPH to NAD+
(hasEvent)	[Pathway:R-CFA-71403] Citric acid cycle (TCA cycle)
(inferredTo)	[Reaction:R-HSA-450984] IDH2 dimer decarboxylates isocitrate

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