Reactome | PKCalpha phosphorylates HuR

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PKCalpha phosphorylates HuR Show undefined attributes

catalystActivity	[CatalystActivity:10258729] calcium,diacylglycerol-dependent serine/threonine kinase activity of PRKCA [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10258731
displayName	PKCalpha phosphorylates HuR
eventOf	[Pathway:R-CFA-450520] HuR (ELAVL1) binds and stabilizes mRNA - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-517674] p-S158,221-HuR binds mRNA - Canis familiaris
inferredFrom	[Reaction:R-HSA-450550] PKCalpha phosphorylates HuR - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-450601] ELAVL1 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	PKCalpha phosphorylates HuR
output	2 × [SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-450576] phospho-ELAVL1 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-450550
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-450520] HuR (ELAVL1) binds and stabilizes mRNA
(precedingEvent)	[Reaction:R-CFA-517674] p-S158,221-HuR binds mRNA
(inferredTo)	[Reaction:R-HSA-450550] PKCalpha phosphorylates HuR

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