Reactome | JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

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JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329421
displayName	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
eventOf	[Pathway:R-CFA-450294] MAP kinase activation - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:20271] JNK cascade
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-450337] Activated TAK1 phosphorylates MKK4/MKK7 - Canis familiaris [Reaction:R-CFA-168162] Phosphorylation of human JNKs by activated MKK4/MKK7 - Canis familiaris [Reaction:R-CFA-450348] Activated human JNKs migrate to nucleoplasm - Canis familiaris
inferredFrom	[Pathway:R-HSA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-450321
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-450294] MAP kinase activation
(inferredTo)	[Pathway:R-HSA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1

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