Reactome | MAP kinase activation

compartment	[Compartment:70101] cytosol [Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329395
displayName	MAP kinase activation
eventOf	[Pathway:R-CFA-448424] Interleukin-17 signaling - Canis familiaris [Pathway:R-CFA-168164] Toll Like Receptor 3 (TLR3) Cascade - Canis familiaris [Pathway:R-CFA-975138] TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation - Canis familiaris [Pathway:R-CFA-166058] MyD88:MAL(TIRAP) cascade initiated on plasma membrane - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:172358] stress-activated MAPK cascade
hasDiagram	true
hasEHLD	false
hasEvent	[Pathway:R-CFA-450321] JNK (c-Jun kinases) phosphorylation and activation mediated by activated human TAK1 - Canis familiaris [Pathway:R-CFA-450302] activated TAK1 mediates p38 MAPK activation - Canis familiaris [Pathway:R-CFA-450282] MAPK targets/ Nuclear events mediated by MAP kinases - Canis familiaris
inferredFrom	[Pathway:R-HSA-450294] MAP kinase activation - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	5
name	MAP kinase activation
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-450294
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

MAP kinase activation Show undefined attributes

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