Reactome | CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2

Schema > Reaction > Entries

CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 Show undefined attributes

catalystActivity	[CatalystActivity:10239664] cyclin-dependent protein serine/threonine kinase activity of Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10283707
displayName	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2
eventOf	[Pathway:R-CFA-2559582] Senescence-Associated Secretory Phenotype (SASP) - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2 - Homo sapiens
input	[SimpleEntity:R-ALL-29358] ATP [nucleoplasm] [Complex:R-CFA-188374] Cyclin A:phospho-Cdk(Thr 160):Cdh1:phosho-APC/C complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2
output	[SimpleEntity:R-ALL-113582] ADP [nucleoplasm] [Complex:R-CFA-188387] Cyclin A:phospho-Cdk2(Thr 160):phospho-Cdh1:phospho-APC/C complex [nucleoplasm]
precedingEvent	[Reaction:R-CFA-3788708] CDKN1A (p21) prevents association of Cyclin A:Cdk2 with Cdh1 - Canis familiaris
regulatedBy	[NegativeRegulation:10283708] Negative regulation by 'Cyclin A:Cdk2:p21/p27 complex [nucleoplasm]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-3788705
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-2559582] Senescence-Associated Secretory Phenotype (SASP)
(inferredTo)	[Reaction:R-HSA-3788705] CDKN1A (p21) prevents phosphorylation of Cdh1 by Cyclin A:Cdk2

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