Reactome | AGT [extracellular region]

compartment	[Compartment:984] extracellular region
componentOf	[Complex:R-CFA-389876] AGTR1:AGT(25-32) [plasma membrane] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-2022399] ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8)) - Canis familiaris [Reaction:R-CFA-2022379] ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7)) - Canis familiaris [Reaction:R-CFA-9615348] AGT(25-32) binds to AGTR2 - Canis familiaris [Reaction:R-CFA-374173] AGT(25-32) binds to AGTR1 - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10249411
displayName	AGT [extracellular region]
endCoordinate	32
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-374187] AGT(25-32) [extracellular region] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-CFA-791492] Ligands of GPCRs that activate Gq/11 [extracellular region] - Canis familiaris
name	AGT AGT(25-32) A0A8I3RR88
producedByEvent	[Reaction:R-CFA-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Canis familiaris [Reaction:R-CFA-2022381] Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Canis familiaris [Reaction:R-CFA-2022383] Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Canis familiaris [Reaction:R-CFA-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Canis familiaris [Reaction:R-CFA-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Canis familiaris
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8I3RR88] UniProt:A0A8I3RR88
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49646] Canis familiaris
stId	R-CFA-374187
startCoordinate	25

(input)	[Reaction:R-CFA-2022399] ENPEP:Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(26-32) (Angiotensin-(2-8)) [Reaction:R-CFA-2022379] ACE2(18-805):Zn2+ hydrolyzes AGT(25-32) (Angiotensin-(1-8)) to AGT(25-31) (Angiotensin-(1-7)) [Reaction:R-CFA-9615348] AGT(25-32) binds to AGTR2 [Reaction:R-CFA-374173] AGT(25-32) binds to AGTR1
(output)	[Reaction:R-CFA-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Reaction:R-CFA-2022381] Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Reaction:R-CFA-2022383] Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Reaction:R-CFA-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Reaction:R-CFA-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
(hasMember)	[DefinedSet:R-CFA-791492] Ligands of GPCRs that activate Gq/11 [extracellular region]
(hasComponent)	[Complex:R-CFA-389876] AGTR1:AGT(25-32) [plasma membrane] [Complex:R-CFA-389873] AGTR2:AGT(25-32) [plasma membrane]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-374187] AGT(25-32) [extracellular region]

AGT [extracellular region] Show undefined attributes

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