Reactome | Autophosphorylation of PTK2 at Y397

Schema > Reaction > Entries

Autophosphorylation of PTK2 at Y397 Show undefined attributes

catalystActivity	[CatalystActivity:10248950] protein tyrosine kinase activity of Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10248952
displayName	Autophosphorylation of PTK2 at Y397
eventOf	[Pathway:R-CFA-354192] Integrin signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-354124] Phosphorylation of pPTK2 by SRC - Canis familiaris
inferredFrom	[Reaction:R-HSA-354073] Autophosphorylation of PTK2 at Y397 - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [Complex:R-CFA-354103] Talin:RIAM complex: ECM ligands:Integrin alphaIIb beta3:Active (p-Y419)- SRC:PTK2 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Autophosphorylation of PTK2 at Y397
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [Complex:R-CFA-354135] Talin:RIAM complex:ECM ligands: alphaIIb beta3:Active p-Y419-SRC:pY397-PTK2 [plasma membrane]
precedingEvent	[Reaction:R-CFA-354066] Translocation of PTK2 to Focal complexes - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-354073
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-354192] Integrin signaling
(precedingEvent)	[Reaction:R-CFA-354124] Phosphorylation of pPTK2 by SRC
(inferredTo)	[Reaction:R-HSA-354073] Autophosphorylation of PTK2 at Y397