Reactome | TP53 Tetramer [nucleoplasm]

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TP53 Tetramer [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-CFA-8952123] RUNX3:TP53 tetramer [nucleoplasm] - Canis familiaris [Complex:R-CFA-3221977] TP53:BANP [nucleoplasm] - Canis familiaris [Complex:R-CFA-6805036] TP53 Tetramer:STK11:NUAK1 [nucleoplasm] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-6805755] EHMT1:EHMT2 dimethylates TP53 - Canis familiaris [Reaction:R-CFA-6805276] CDK5 phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6805109] CDK2 phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6805399] TAF1 phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-5633460] MDM2 binds TP53 - Canis familiaris [Reaction:R-CFA-6805470] AMPK phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6805479] TP53RK phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-5693609] ATM phosphorylates TP53 at S15 - Canis familiaris [Reaction:R-CFA-6799332] ATR phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-8952128] RUNX3 binds TP53 - Canis familiaris [Reaction:R-CFA-3221982] BANP binds TP53 - Canis familiaris [Reaction:R-CFA-6805103] AURKA phosphorylates TP53 - Canis familiaris [Reaction:R-CFA-6799431] TP53 binds HIPK1 - Canis familiaris [Reaction:R-CFA-9836362] p-PKR dimer phosphorylates TP53 tetramer - Canis familiaris [Reaction:R-CFA-6805035] TP53 binds STK11 and NUAK1 - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10281716
displayName	TP53 Tetramer [nucleoplasm]
hasComponent	4 × [EntityWithAccessionedSequence:R-CFA-69488] TP53 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-3209194] TP53 Tetramer [nucleoplasm] - Homo sapiens
maxDepth	2
name	TP53 Tetramer
producedByEvent	[Reaction:R-CFA-6804762] TP53 forms homotetramers - Canis familiaris [Reaction:R-CFA-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-3209194
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-CFA-8952128] RUNX3 binds TP53 [Reaction:R-CFA-6805755] EHMT1:EHMT2 dimethylates TP53 [Reaction:R-CFA-3221982] BANP binds TP53 [Reaction:R-CFA-6805035] TP53 binds STK11 and NUAK1 [Reaction:R-CFA-6805276] CDK5 phosphorylates TP53 [Reaction:R-CFA-6805109] CDK2 phosphorylates TP53 [Reaction:R-CFA-6805103] AURKA phosphorylates TP53 [Reaction:R-CFA-6805399] TAF1 phosphorylates TP53 [Reaction:R-CFA-6799431] TP53 binds HIPK1 [Reaction:R-CFA-9836362] p-PKR dimer phosphorylates TP53 tetramer [Reaction:R-CFA-5633460] MDM2 binds TP53 [Reaction:R-CFA-6805470] AMPK phosphorylates TP53 [Reaction:R-CFA-6805479] TP53RK phosphorylates TP53 [Reaction:R-CFA-5693609] ATM phosphorylates TP53 at S15 [Reaction:R-CFA-6799332] ATR phosphorylates TP53
(hasComponent)	[Complex:R-CFA-8952123] RUNX3:TP53 tetramer [nucleoplasm] [Complex:R-CFA-3221977] TP53:BANP [nucleoplasm] [Complex:R-CFA-6805037] TP53 Tetramer:STK11:p-T211-NUAK1 [nucleoplasm] [Complex:R-CFA-6805036] TP53 Tetramer:STK11:NUAK1 [nucleoplasm] [Complex:R-CFA-6799433] TP53 Tetramer:HIPK1 [nucleoplasm] [Complex:R-CFA-6804885] p-S166,S188-MDM2 dimer, p-S166,S188-MDM2,MDM4:TP53 [nucleoplasm]
(output)	[Reaction:R-CFA-3215310] USP7 deubiquitinates TP53 and counteracts MDM2 [Reaction:R-CFA-6804762] TP53 forms homotetramers
(inferredTo)	[Complex:R-HSA-3209194] TP53 Tetramer [nucleoplasm]

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