Reactome | Nuclear Envelope Breakdown

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Nuclear Envelope Breakdown Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10331001
displayName	Nuclear Envelope Breakdown
eventOf	[Pathway:R-CFA-68875] Mitotic Prophase - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:18555] mitotic nuclear membrane disassembly
hasDiagram	false
hasEHLD	false
hasEvent	[Pathway:R-CFA-2980767] Activation of NIMA Kinases NEK9, NEK6, NEK7 - Canis familiaris [Pathway:R-CFA-3301854] Nuclear Pore Complex (NPC) Disassembly - Canis familiaris [Reaction:R-CFA-2993898] VRK1/VRK2 phosphorylate BANF1 - Canis familiaris [Pathway:R-CFA-4419969] Depolymerization of the Nuclear Lamina - Canis familiaris
inferredFrom	[Pathway:R-HSA-2980766] Nuclear Envelope Breakdown - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	3
name	Nuclear Envelope Breakdown
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-2980766
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-68875] Mitotic Prophase
(inferredTo)	[Pathway:R-HSA-2980766] Nuclear Envelope Breakdown

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