Reactome | Spherical HDL binds membrane-associated free cholesterol and phospholipids

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Spherical HDL binds membrane-associated free cholesterol and phospholipids Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10248408
displayName	Spherical HDL binds membrane-associated free cholesterol and phospholipids
eventOf	[Pathway:R-CFA-8964058] HDL remodeling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-266299] Spherical HDL binds membrane-associated free cholesterol and phospholipids - Homo sapiens
input	2 × [SimpleEntity:R-ALL-171095] CHOL [plasma membrane] 2 × [SimpleEntity:R-ALL-171142] PL [plasma membrane] [Complex:R-CFA-265523] spherical HDL [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Spherical HDL binds membrane-associated free cholesterol and phospholipids
output	[Complex:R-CFA-8855688] enlarged spherical HDL [extracellular region]
precedingEvent	[Reaction:R-CFA-266082] ABCG1-mediated transport of intracellular cholesterol to the cell surface - Canis familiaris
regulatedBy	[PositiveRegulation:10248409] Positive regulation by 'PLTP [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-266299
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-8964058] HDL remodeling
(inferredTo)	[Reaction:R-HSA-266299] Spherical HDL binds membrane-associated free cholesterol and phospholipids

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