Reactome | ERKs are inactivated

Schema > Pathway > Entries

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329831
displayName	ERKs are inactivated
eventOf	[Pathway:R-CFA-198753] ERK/MAPK targets - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-199959] ERKs are inactivated by protein phosphatase 2A - Canis familiaris [Reaction:R-CFA-203797] ERKs are inactivated by dual-specific phosphatases (DUSPs) - Canis familiaris
inferredFrom	[Pathway:R-HSA-202670] ERKs are inactivated - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	ERKs are inactivated
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-202670
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CFA-198753] ERK/MAPK targets
(inferredTo)	[Pathway:R-HSA-202670] ERKs are inactivated

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