Reactome | SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol

Schema > Reaction > Entries

SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10243930] sodium-dependent multivitamin transmembrane transporter activity of SLC5A6:PDZD11 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10243932
displayName	SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol
eventOf	[Pathway:R-CFA-199220] Vitamin B5 (pantothenate) metabolism - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-196857] PANK2 phosphorylates PanK - Canis familiaris [Reaction:R-CFA-199203] PANK1/3 phosphorylate PanK - Canis familiaris
inferredFrom	[Reaction:R-HSA-199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - Homo sapiens
input	2 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region] [SimpleEntity:R-ALL-199192] PanK [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol (R)-pantothenate(out) + 2 Na(+)(out) = (R)-pantothenate(in) + 2 Na(+)(in)
output	2 × [SimpleEntity:R-ALL-83910] Na+ [cytosol] [SimpleEntity:R-ALL-196820] PanK [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-199206
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-199220] Vitamin B5 (pantothenate) metabolism
(precedingEvent)	[Reaction:R-CFA-196857] PANK2 phosphorylates PanK [Reaction:R-CFA-199203] PANK1/3 phosphorylate PanK
(inferredTo)	[Reaction:R-HSA-199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol

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