Reactome | PANK1/3 phosphorylate PanK

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PANK1/3 phosphorylate PanK Show undefined attributes

catalystActivity	[CatalystActivity:10243917] pantothenate kinase activity of PANK1/3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10243919
displayName	PANK1/3 phosphorylate PanK
eventOf	[Pathway:R-CFA-196783] Coenzyme A biosynthesis - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-8938300] Vanin hydrolyses pantetheine to PanK, 2AET - Canis familiaris [Reaction:R-CFA-196753] 2xPPCS ligates PPanK with Cys - Canis familiaris
inferredFrom	[Reaction:R-HSA-199203] PANK1/3 phosphorylate PanK - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-196820] PanK [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PANK1/3 phosphorylate PanK (R)-pantothenate + ATP => (R)-4'-phosphopantothenate + ADP + H(+) Pantothenate is phosphorylated [PANK1;3;4]
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-196786] PPanK [cytosol]
precedingEvent	[Reaction:R-CFA-199206] SLC5A6 cotransports extracellular PanK and 2Na+ to cytosol - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-199203
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-196783] Coenzyme A biosynthesis
(precedingEvent)	[Reaction:R-CFA-8938300] Vanin hydrolyses pantetheine to PanK, 2AET [Reaction:R-CFA-196753] 2xPPCS ligates PPanK with Cys
(inferredTo)	[Reaction:R-HSA-199203] PANK1/3 phosphorylate PanK

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