Reactome | ERBB4 forms heterodimers with EGFR

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ERBB4 forms heterodimers with EGFR Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10272624
displayName	ERBB4 forms heterodimers with EGFR
eventOf	[Pathway:R-CFA-1236394] Signaling by ERBB4 - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1977959] ERBB4 forms heterodimers with EGFR - Homo sapiens
input	[Complex:R-CFA-179847] EGF:EGFR [plasma membrane] [DefinedSet:R-CFA-1236393] NRGs/EGF-like ligands:ERBB4 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	ERBB4 forms heterodimers with EGFR
output	[Complex:R-CFA-1977956] ERBB4:EGFR heterodimer [plasma membrane]
precedingEvent	[Reaction:R-CFA-1236398] ERBB4 binds NRGs or EGF-like ligands - Canis familiaris [Reaction:R-CFA-177942] EGFR binds EGF ligand - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1977959
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1236394] Signaling by ERBB4
(inferredTo)	[Reaction:R-HSA-1977959] ERBB4 forms heterodimers with EGFR

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