Reactome | ERBB4 binds NRGs or EGF-like ligands

Schema > Reaction > Entries

ERBB4 binds NRGs or EGF-like ligands Show undefined attributes

category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10266044
displayName	ERBB4 binds NRGs or EGF-like ligands
eventOf	[Pathway:R-CFA-1236394] Signaling by ERBB4 - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-1977959] ERBB4 forms heterodimers with EGFR - Canis familiaris [Reaction:R-CFA-1977958] ERBB4 forms heterodimers with ERBB3 - Canis familiaris [Reaction:R-CFA-1250220] Homodimerization of ERBB4 - Canis familiaris [Reaction:R-CFA-1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 - Canis familiaris
inferredFrom	[Reaction:R-HSA-1236398] ERBB4 binds NRGs or EGF-like ligands - Homo sapiens
input	[EntityWithAccessionedSequence:R-CFA-1227940] ERBB4 [plasma membrane] 3 × [DefinedSet:R-CFA-1233236] NRGs/EGF-like ligands [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	ERBB4 binds NRGs or EGF-like ligands ERBB4 binds neuregulins or EGF-like ligands NRGs/EGF-like ligands + ERBB4 => NRGs/EGF-like ligands:ERBB4
output	[DefinedSet:R-CFA-1236393] NRGs/EGF-like ligands:ERBB4 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1236398
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-CFA-1977959] ERBB4 forms heterodimers with EGFR [Reaction:R-CFA-1977958] ERBB4 forms heterodimers with ERBB3 [Reaction:R-CFA-1963589] ERBB2 forms heterodimers with ligand-activated ERBB receptors: EGFR, ERBB3 and ERBB4 [Reaction:R-CFA-1250220] Homodimerization of ERBB4
(hasEvent)	[Pathway:R-CFA-1236394] Signaling by ERBB4
(inferredTo)	[Reaction:R-HSA-1236398] ERBB4 binds NRGs or EGF-like ligands

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