Reactome | Removal of the Flap Intermediate from the C-strand

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Removal of the Flap Intermediate from the C-strand Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10329555
displayName	Removal of the Flap Intermediate from the C-strand
eventOf	[Pathway:R-CFA-174414] Processive synthesis on the C-strand of the telomere - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:263978] telomere maintenance via semi-conservative replication
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-174445] RPA binds to the Flap on the C-strand - Canis familiaris [Reaction:R-CFA-174451] Recruitment of DNA2 endonuclease to the C strand - Canis familiaris [Reaction:R-CFA-174441] Removal of RNA primer and dissociation of RPA and Dna2 from the C-strand - Canis familiaris [Reaction:R-CFA-174446] Removal of remaining Flap from the C-strand - Canis familiaris
inferredFrom	[Pathway:R-HSA-174437] Removal of the Flap Intermediate from the C-strand - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Removal of the Flap Intermediate from the C-strand
precedingEvent	[Reaction:R-CFA-174438] Formation of the Flap Intermediate on the C-strand - Canis familiaris
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-174437
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-174414] Processive synthesis on the C-strand of the telomere
(inferredTo)	[Pathway:R-HSA-174437] Removal of the Flap Intermediate from the C-strand

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