Reactome | LCK [cytosol]

Schema > EntityWithAccessionedSequence > Entries

candidateOf	[CandidateSet:R-CFA-453105] SHC kinases in IL2 signaling [cytosol] - Canis familiaris
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-CFA-9706263] active FLT3:LCK [plasma membrane] - Canis familiaris [Complex:R-CFA-202157] Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-9706312] Active FLT3 binds to LCK - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10245169
displayName	LCK [cytosol]
endCoordinate	509
inDisease	false
inferredFrom	[EntityWithAccessionedSequence:R-HSA-167609] LCK [cytosol] - Homo sapiens
maxDepth	1
memberOf	[DefinedSet:R-CFA-434838] p-Y348-SYK/LCK [cytosol] - Canis familiaris [DefinedSet:R-CFA-389743] LCK, CSK [cytosol] - Canis familiaris [CandidateSet:R-CFA-9018917] RHOH effectors [cytosol] - Canis familiaris [DefinedSet:R-CFA-211064] Src family tyrosine kinases (SFKs) [cytosol] - Canis familiaris
name	LCK LCK A0A8I3NAC6
referenceEntity	[ReferenceGeneProduct:uniprot:A0A8I3NAC6] UniProt:A0A8I3NAC6
referenceType	ReferenceGeneProduct
schemaClass	EntityWithAccessionedSequence
species	[Species:49646] Canis familiaris
stId	R-CFA-167609
startCoordinate	1

(hasMember)	[CandidateSet:R-CFA-9018917] RHOH effectors [cytosol] [DefinedSet:R-CFA-434838] p-Y348-SYK/LCK [cytosol] [DefinedSet:R-CFA-389743] LCK, CSK [cytosol] [DefinedSet:R-CFA-211064] Src family tyrosine kinases (SFKs) [cytosol] [DefinedSet:R-CFA-2396556] SYK/LCK/ZAP-70 [cytosol] [DefinedSet:R-CFA-2395419] FYN,LCK [cytosol]
(input)	[Reaction:R-CFA-9706312] Active FLT3 binds to LCK
(hasComponent)	[Complex:R-CFA-9706263] active FLT3:LCK [plasma membrane] [Complex:R-CFA-202157] Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane]
(hasCandidate)	[CandidateSet:R-CFA-453105] SHC kinases in IL2 signaling [cytosol]
(activeUnit)	[CatalystActivity:10245275] protein tyrosine kinase activity of Antigen-bearing MHC Class II : TCR complex:CD4:Lck [plasma membrane]
(inferredTo)	[EntityWithAccessionedSequence:R-HSA-167609] LCK [cytosol]