Reactome | Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers

Schema > Reaction > Entries

Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers Show undefined attributes

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol [Compartment:984] extracellular region
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10266578
displayName	Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers
eventOf	[Pathway:R-CFA-1250347] SHC1 events in ERBB4 signaling - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CFA-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Canis familiaris
inferredFrom	[Reaction:R-HSA-1250380] Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers - Homo sapiens
input	[Complex:R-CFA-109797] GRB2-1:SOS1 [cytosol] [Complex:R-CFA-1250343] p-Y349,350-SHC1:p-ERBB4 [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers
output	[Complex:R-CFA-1250382] GRB2:SOS1:p-Y349,350-SHC1:p-ERBB4 [plasma membrane]
precedingEvent	[Reaction:R-CFA-1250348] Phosphorylation of SHC1 by ERBB4 homodimers - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1250380
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1250347] SHC1 events in ERBB4 signaling
(precedingEvent)	[Reaction:R-CFA-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4
(inferredTo)	[Reaction:R-HSA-1250380] Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers

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