Reactome | SHC1 events in ERBB4 signaling

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SHC1 events in ERBB4 signaling Show undefined attributes

created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10330681
displayName	SHC1 events in ERBB4 signaling
eventOf	[Pathway:R-CFA-1236394] Signaling by ERBB4 - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CFA-1250357] SHC1 binds P-ERBB4 isoform dimers - Canis familiaris [Reaction:R-CFA-1250348] Phosphorylation of SHC1 by ERBB4 homodimers - Canis familiaris [Reaction:R-CFA-1250380] Recruitment of GRB2:SOS1 to phosphorylated SHC1 in complex with phosphorylated ERBB4 homodimers - Canis familiaris [Reaction:R-CFA-1250383] RAS guanyl-nucleotide exchange mediated by SOS1 in complex with GRB2 and p-Y349,350-SHC1:p-ERBB4 - Canis familiaris
inferredFrom	[Pathway:R-HSA-1250347] SHC1 events in ERBB4 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	SHC1 events in ERBB4 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:49646] Canis familiaris
stId	R-CFA-1250347
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1236394] Signaling by ERBB4
(inferredTo)	[Pathway:R-HSA-1250347] SHC1 events in ERBB4 signaling

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