Reactome | SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB

Schema > Reaction > Entries

SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10265584
displayName	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB
eventOf	[Pathway:R-CFA-1169091] Activation of NF-kappaB in B cells - Canis familiaris
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[BlackBoxEvent:R-CFA-1168643] SCF-beta-TrCP ubiquitinylates IkB - Canis familiaris
inferredFrom	[Reaction:R-HSA-1168642] SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB - Homo sapiens
input	[Complex:R-CFA-1168592] CUL1:FBXW11:SKP1 [cytosol] [Complex:R-CFA-1168594] NF-kappaB p65:p65:p-IKB [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB
output	[Complex:R-CFA-1168617] NF-kappaB:p-IkB:SCF-betaTrCP [cytosol]
precedingEvent	[Reaction:R-CFA-1168638] Activated IKK phosphorylates I-kappaB - Canis familiaris
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:49646] Canis familiaris
stId	R-CFA-1168642
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CFA-1169091] Activation of NF-kappaB in B cells
(precedingEvent)	[BlackBoxEvent:R-CFA-1168643] SCF-beta-TrCP ubiquitinylates IkB
(inferredTo)	[Reaction:R-HSA-1168642] SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB

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