Reactome | CUL1:FBXW11:SKP1 [cytosol]

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CUL1:FBXW11:SKP1 [cytosol] Show undefined attributes

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-CFA-3000340] p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] - Canis familiaris [Complex:R-CFA-1168617] NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-3000339] Phosphorylated BORA binds SCF-beta-TrCp1/2 - Canis familiaris [Reaction:R-CFA-5607723] SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB - Canis familiaris [Reaction:R-CFA-1168642] SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10265580
displayName	CUL1:FBXW11:SKP1 [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-CFA-174230] CUL1 [cytosol] [EntityWithAccessionedSequence:R-CFA-976035] FBXW11 [cytosol] [EntityWithAccessionedSequence:R-CFA-174150] SKP1 [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-5607687] SCF-beta-TRCP [cytosol] - Homo sapiens [DefinedSet:R-HSA-1168601] (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] - Homo sapiens [Complex:R-HSA-1168592] CUL1:FBXW11:SKP1 [cytosol] - Homo sapiens
maxDepth	2
name	CUL1:FBXW11:SKP1
producedByEvent	[Reaction:R-CFA-3000335] SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA - Canis familiaris [BlackBoxEvent:R-CFA-1168643] SCF-beta-TrCP ubiquitinylates IkB - Canis familiaris [BlackBoxEvent:R-CFA-5607725] SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-1168592
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(input)	[Reaction:R-CFA-5607723] SCF-beta-TRCP binds p-7S-p100 in active NIK:p-S176,180-IKKA dimer:p-7S-p100:RELB [Reaction:R-CFA-3000339] Phosphorylated BORA binds SCF-beta-TrCp1/2 [Reaction:R-CFA-1168642] SCF with beta-TrCP1 or beta-TrCP2 binds NF-kappaB:phospho-IkB
(output)	[Reaction:R-CFA-3000335] SCF-beta-TrCp1/2 ubiquitinates phosphorylated BORA [BlackBoxEvent:R-CFA-1168643] SCF-beta-TrCP ubiquitinylates IkB [BlackBoxEvent:R-CFA-5607725] SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP
(activeUnit)	[CatalystActivity:10281415] ubiquitin-protein transferase activity of p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] [CatalystActivity:10288931] ubiquitin-protein transferase activity of Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol]
(hasComponent)	[Complex:R-CFA-3000340] p-8S,3T-BORA:SCF-beta-TrCp1/2 [cytosol] [Complex:R-CFA-1168617] NF-kappaB:p-IkB:SCF-betaTrCP [cytosol] [Complex:R-CFA-5607693] Active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP [cytosol] [Complex:R-CFA-5684270] SCF-beta-TrCP1,2:p-S927,S932-NFKB1:p-S,T-MAP3K8:TNIP2 [cytosol]
(inferredTo)	[Complex:R-HSA-5607687] SCF-beta-TRCP [cytosol] [DefinedSet:R-HSA-1168601] (BTRC:CUL1:SKP1),(FBXW11:CUL1:SKP1) [cytosol] [Complex:R-HSA-1168592] CUL1:FBXW11:SKP1 [cytosol]

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