Reactome | POLZ [nucleoplasm]

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POLZ [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-CFA-5652152] POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] - Canis familiaris [Complex:R-CFA-5656146] POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] - Canis familiaris [Complex:R-CFA-5655852] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm] - Canis familiaris
consumedByEvent	[Reaction:R-CFA-5652151] REV1 recruits POLZ to (AP:Cyt)-DNA Template - Canis familiaris [Reaction:R-CFA-5656105] POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA - Canis familiaris [Reaction:R-CFA-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template - Canis familiaris
created	[InstanceEdit:10226222] Weiser, Joel, 2026-03-16
dbId	10233806
displayName	POLZ [nucleoplasm]
hasComponent	[EntityWithAccessionedSequence:R-CFA-59092] MAD2L2 [nucleoplasm] [EntityWithAccessionedSequence:R-CFA-110278] REV3L [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-110279] POLZ [nucleoplasm] - Homo sapiens
maxDepth	2
name	POLZ
producedByEvent	[Reaction:R-CFA-110311] POLZ extends translesion synthesis - Canis familiaris [Reaction:R-CFA-110322] Formation of Pol zeta complex - Canis familiaris [Reaction:R-CFA-5656158] POLZ elongates POLI-incorporated dNMP - Canis familiaris [Reaction:R-CFA-5655965] POLK and POLZ cooperate in elongation of mispaired primer termini - Canis familiaris
schemaClass	Complex
species	[Species:49646] Canis familiaris
stId	R-CFA-110279
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(output)	[Reaction:R-CFA-5656158] POLZ elongates POLI-incorporated dNMP [Reaction:R-CFA-110311] POLZ extends translesion synthesis [Reaction:R-CFA-110322] Formation of Pol zeta complex [Reaction:R-CFA-5655965] POLK and POLZ cooperate in elongation of mispaired primer termini
(activeUnit)	[CatalystActivity:10291934] DNA-directed DNA polymerase activity of POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] [CatalystActivity:10233813] DNA-directed DNA polymerase activity of POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm]
(input)	[Reaction:R-CFA-5656105] POLI simultaneously binds REV1 and monoUb:K164-PCNA at damaged DNA [Reaction:R-CFA-5652151] REV1 recruits POLZ to (AP:Cyt)-DNA Template [Reaction:R-CFA-5655835] POLK forms a quaternary complex with REV1 and POLZ on damaged DNA template
(hasComponent)	[Complex:R-CFA-5656146] POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(EtAD:T)-DNA Template,(Gamma-HOPdG:C)-DNA Template [nucleoplasm] [Complex:R-CFA-5656097] POLI:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:EtAD-DNA Template,Gamma-HOPdG-DNA Template [nucleoplasm] [Complex:R-CFA-5652152] POLZ:REV1:MonoUb:K164-PCNA:RPA:RFC:(AP:Cyt)-DNA Template [nucleoplasm] [Complex:R-CFA-5655912] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:(Tg:A)-DNA Template,(OGUA:A)-DNA Template,(BPDE-G:C)-DNA Template [nucleoplasm] [Complex:R-CFA-5655852] POLK:REV1:POLZ:MonoUb:K164-PCNA:RPA:RFC:Tg-DNA Template,OGUA-DNA Template,BPDE-G-DNA Template [nucleoplasm]
(inferredTo)	[Complex:R-HSA-110279] POLZ [nucleoplasm]

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