Reactome | SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH

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SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH Show undefined attributes

catalystActivity	[CatalystActivity:10991968] very long-chain fatty acid-CoA ligase activity of SLC27A2 [peroxisomal membrane]
category	transition
compartment	[Compartment:17951] peroxisomal matrix
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10991970
displayName	SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH
eventOf	[Pathway:R-CEL-390247] Beta-oxidation of very long chain fatty acids - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-390256] ACOX1 oxidizes C26:0 CoA - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-9914143] SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH - Homo sapiens
input	[SimpleEntity:R-ALL-389573] ATP [peroxisomal matrix] [SimpleEntity:R-ALL-193514] CoA-SH [peroxisomal matrix] [SimpleEntity:R-ALL-9914044] VLCFA [peroxisomal matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH a very long-chain fatty acid + ATP + CoA => a very long-chain fatty acyl-CoA + AMP + diphosphate
output	[SimpleEntity:R-ALL-389620] AMP [peroxisomal matrix] [SimpleEntity:R-ALL-389593] PPi [peroxisomal matrix] [SimpleEntity:R-ALL-9914131] VLCFA-CoA [peroxisomal matrix]
precedingEvent	[Reaction:R-CEL-390393] Peroxisomal uptake of very long-chain fatty acyl CoA - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-9914143
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-390247] Beta-oxidation of very long chain fatty acids
(precedingEvent)	[Reaction:R-CEL-390256] ACOX1 oxidizes C26:0 CoA
(inferredTo)	[Reaction:R-HSA-9914143] SLC27A2-mediated ligation of peroxisomal fatty acid and CoASH

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