Reactome | Interaction of E3 with substrate and E2-Ub complex

Schema > Reaction > Entries

Interaction of E3 with substrate and E2-Ub complex Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10945505
displayName	Interaction of E3 with substrate and E2-Ub complex
eventOf	[Pathway:R-CEL-983168] Antigen processing: Ubiquitination & Proteasome degradation - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-983140] Transfer of Ub from E2 to substrate and release of E2 - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-983157] Interaction of E3 with substrate and E2-Ub complex - Homo sapiens
input	[OtherEntity:R-ALL-983035] antigenic substrate [cytosol] [CandidateSet:R-CEL-976075] E3 ligases in proteasomal degradation [cytosol] [Complex:R-CEL-976165] Ubiquitin:E2 conjugating enzymes [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Interaction of E3 with substrate and E2-Ub complex
output	[Complex:R-CEL-983126] Ag-substrate:E3:E2:Ub [cytosol]
precedingEvent	[Reaction:R-CEL-983152] Transfer of ubiquitin from E1 to E2 - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-983157
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-983168] Antigen processing: Ubiquitination & Proteasome degradation
(precedingEvent)	[Reaction:R-CEL-983140] Transfer of Ub from E2 to substrate and release of E2
(inferredTo)	[Reaction:R-HSA-983157] Interaction of E3 with substrate and E2-Ub complex

Cite Us!