Reactome | E3 ligases in proteasomal degradation [cytosol]

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E3 ligases in proteasomal degradation [cytosol] Show undefined attributes

catalystActivities	[CatalystActivity:10945425] ubiquitin-protein transferase activity of E3 ligases in proteasomal degradation [cytosol]
compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-CEL-983126] Ag-substrate:E3:E2:Ub [cytosol] - Caenorhabditis elegans
consumedByEvent	[Reaction:R-CEL-983157] Interaction of E3 with substrate and E2-Ub complex - Caenorhabditis elegans
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10945352
displayName	E3 ligases in proteasomal degradation [cytosol]
hasCandidate	[EntityWithAccessionedSequence:R-CEL-976009] sli-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-975970] chn-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-975995] wwp-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-975971] mgrn-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-975992] NEDD4 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-975976] RNF25 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976033] TRIM11 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976020] TRIM63 [cytosol] - Caenorhabditis elegans [DefinedSet:R-CEL-976048-3] Homologues of SPSB2 [cytosol] - Caenorhabditis elegans [DefinedSet:R-CEL-976023-2] Homologues of SPSB4 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976043] oxi-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976012] etc-1 [cytosol] - Caenorhabditis elegans [Complex:R-CEL-976093] RBX1-CUL2-EloB,C-VHL [cytosol] - Caenorhabditis elegans [Complex:R-CEL-976101] RBX1:CUL3:BTB [cytosol] - Caenorhabditis elegans [Complex:R-CEL-976079] RBX1:CUL5:EloB/C:LRRC41 [cytosol] - Caenorhabditis elegans [Complex:R-CEL-976109] RNF7 (RBX2):CUL5:EloB/C:ASB [cytosol] - Caenorhabditis elegans [Complex:R-CEL-976147] RBX1-CUL5-EloB/C-SOCS [cytosol] - Caenorhabditis elegans [Complex:R-CEL-976123] APC/C E3 ligase complex [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976045] ubr-4 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-201579] pdr-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976036] FBXO17 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976039] FBXO27 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976031] FBXO44 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-975987] ARIH2 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976042] lep-2 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976019] lrch-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-975984] dcaf-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-5688967] LTN1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-5688974] RNF14 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-5688973] gldi-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-5688971] TRIM39 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-5688975] TRIM41 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-5688976] TRIM50 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-5688970] ufl-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-8851650] tag-30 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-8851656] hecw-1 [cytosol] - Caenorhabditis elegans [DefinedSet:R-CEL-8851651-3] Homologues of HERC3 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-8851645] herc-1 [cytosol] - Caenorhabditis elegans [DefinedSet:R-CEL-8851641-3] Homologues of LNX1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-8851640] mex-3 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-8851652] trul-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-8851647] UBE3D [cytosol] - Caenorhabditis elegans
hasMember	[EntityWithAccessionedSequence:R-CEL-174230] cul-1 [cytosol] - Caenorhabditis elegans [DefinedSet:R-CEL-975969-3] Homologues of RNF19B [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-1472879] mib-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976003] NEDD4L [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-374563] SIAH1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976024] spsb-1 [cytosol] - Caenorhabditis elegans [DefinedSet:R-CEL-936553-3] Homologues of HERC5 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976018] RBCK1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-374566] SIAH2 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976051] TRIM21 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-5688977] TRIM69 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976055] ubr-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-975983] eel-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-976029] madd-2 [cytosol] - Caenorhabditis elegans [Complex:R-CEL-976110] SCF E3 ubiquitin ligase [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-8850895] rbpl-1 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-8850909] RNF19A [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-8850903] ZNRF1 [cytosol] - Caenorhabditis elegans [DefinedSet:R-CEL-8850906-3] Homologues of HERC6 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-8850901] ZNRF2 [cytosol] - Caenorhabditis elegans [EntityWithAccessionedSequence:R-CEL-8850900] unk-1 [cytosol] - Caenorhabditis elegans
inDisease	false
inferredFrom	[CandidateSet:R-HSA-976075] E3 ligases in proteasomal degradation [cytosol] - Homo sapiens
maxDepth	5
name	E3 ligases in proteasomal degradation
producedByEvent	[Reaction:R-CEL-983147] Release of E3 from polyubiquitinated substrate - Caenorhabditis elegans
schemaClass	CandidateSet
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-976075

Referrals

(hasComponent)	[Complex:R-CEL-983126] Ag-substrate:E3:E2:Ub [cytosol] [Complex:R-CEL-983131] E3:Ub:substrate [cytosol] [Complex:R-CEL-983134] E3:K48-polyubiquitinated substrate [cytosol]
(input)	[Reaction:R-CEL-983157] Interaction of E3 with substrate and E2-Ub complex
(output)	[Reaction:R-CEL-983147] Release of E3 from polyubiquitinated substrate
(inferredTo)	[CandidateSet:R-HSA-976075] E3 ligases in proteasomal degradation [cytosol]
(activeUnit)	[CatalystActivity:10945501] ubiquitin-protein transferase activity of E3:Ub:substrate [cytosol]
(physicalEntity)	[CatalystActivity:10945425] ubiquitin-protein transferase activity of E3 ligases in proteasomal degradation [cytosol]

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