Reactome | ISGylation of DDX58

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10943701
displayName	ISGylation of DDX58
eventOf	[Pathway:R-CEL-936440] Negative regulators of DDX58/IFIH1 signaling - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-936563] ISGylation of DDX58 - Homo sapiens
input	[EntityWithAccessionedSequence:R-CEL-168917] DDX58 [cytosol] [Complex:R-CEL-936560] ISG15:UBEIL/UbcH8:CEB1 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ISGylation of DDX58 ISGylation of RIG-I
output	[Complex:R-CEL-936557] ISG15:DDX58 conjugate [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-936563
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CEL-936440] Negative regulators of DDX58/IFIH1 signaling
(inferredTo)	[Reaction:R-HSA-936563] ISGylation of DDX58

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