Reactome | Negative regulators of DDX58/IFIH1 signaling

Schema > Pathway > Entries

Negative regulators of DDX58/IFIH1 signaling Show undefined attributes

created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10994917
displayName	Negative regulators of DDX58/IFIH1 signaling
eventOf	[Pathway:R-CEL-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:261603] negative regulation of type I interferon production
hasDiagram	false
hasEHLD	false
hasEvent	[BlackBoxEvent:R-CEL-936390] CYLD mediated deubiquitination of DDX58 (RIG-I) - Caenorhabditis elegans [Reaction:R-CEL-936563] ISGylation of DDX58 - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-936440] Negative regulators of DDX58/IFIH1 signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Negative regulators of DDX58/IFIH1 signaling Negative regulators of RIG-I/MDA5 signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-936440
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-168928] DDX58/IFIH1-mediated induction of interferon-alpha/beta
(inferredTo)	[Pathway:R-HSA-936440] Negative regulators of DDX58/IFIH1 signaling

© 2026 Reactome

Cite Us!