Reactome | GDIs block activation of RHOA

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10986287
displayName	GDIs block activation of RHOA
eventOf	[Pathway:R-CEL-8980692] RHOA GTPase cycle - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9012835] GDIs block activation of RHOA - Homo sapiens
input	[EntityWithAccessionedSequence:R-CEL-194478] rhi-1 [cytosol] [Complex:R-CEL-8964174] RHOA:GDP [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	GDIs block activation of RHOA
output	[Complex:R-CEL-9012838] RHOA GDIs:RHOA:GDP [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-9012835
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-CEL-8980692] RHOA GTPase cycle
(inferredTo)	[Reaction:R-HSA-9012835] GDIs block activation of RHOA

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