Reactome | Synthesis of very long-chain fatty acyl-CoAs

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Synthesis of very long-chain fatty acyl-CoAs Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10994387
displayName	Synthesis of very long-chain fatty acyl-CoAs
eventOf	[Pathway:R-CEL-75105] Fatty acyl-CoA biosynthesis - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:539094] long-chain fatty-acyl-CoA biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-CEL-201035] ACSL1,3,5,6 ligate CoA to PALM to form PALM-CoA - Caenorhabditis elegans [Reaction:R-CEL-548843] ACSL3,4 ligate CoA to AA to form AA-CoA - Caenorhabditis elegans [Reaction:R-CEL-548814] ELOVL3,6,7 elongate PALM-CoA and Mal-CoA to 3OOD-CoA - Caenorhabditis elegans [Reaction:R-CEL-548800] ELOVL1,2,3,5 elongate AA-CoA and Mal-CoA to 3ODCT-CoA - Caenorhabditis elegans [Reaction:R-CEL-548818] HSD17B3,12 hydrogenates 3OOD-CoA to 3HODC-CoA - Caenorhabditis elegans [Reaction:R-CEL-5676637] PTPLs dehydrate VLC3HA-CoA to VLCTDA-CoA - Caenorhabditis elegans [Reaction:R-CEL-548831] TECR,TECRL dehydrogenate TOD-CoA to ST-CoA - Caenorhabditis elegans
inferredFrom	[Pathway:R-HSA-75876] Synthesis of very long-chain fatty acyl-CoAs - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Synthesis of very long-chain fatty acyl-CoAs Conversion of palmitic acid to very long chain fatty acyl-CoAs
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-75876
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-75105] Fatty acyl-CoA biosynthesis
(inferredTo)	[Pathway:R-HSA-75876] Synthesis of very long-chain fatty acyl-CoAs

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