Reactome | GOT2 transaminates OA and L-Glu

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GOT2 transaminates OA and L-Glu Show undefined attributes

catalystActivity	[CatalystActivity:10915755] L-aspartate:2-oxoglutarate aminotransferase activity of GOT2 dimer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10914110] Weiser, Joel, 2026-03-16
dbId	10915831
displayName	GOT2 transaminates OA and L-Glu
eventOf	[Pathway:R-CEL-9856872] Malate-aspartate shuttle - Caenorhabditis elegans [Pathway:R-CEL-8964539] Glutamate and glutamine metabolism - Caenorhabditis elegans
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-CEL-372448] SLC25A12,13 exchange L-Glu and L-Asp - Caenorhabditis elegans [Reaction:R-CEL-372480] 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix] - Caenorhabditis elegans [Reaction:R-CEL-376851] SLC25A11 exchanges 2-OG and MAL - Caenorhabditis elegans
inferredFrom	[Reaction:R-HSA-70613] GOT2 transaminates OA and L-Glu - Homo sapiens
input	[SimpleEntity:R-ALL-113552] L-Glu [mitochondrial matrix] [SimpleEntity:R-ALL-113587] OA [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	GOT2 transaminates OA and L-Glu L-glutamate + oxaloacetate => 2-oxoglutarate + L-aspartate GOT2 transaminates oxaloacetate and glutamate
output	[SimpleEntity:R-ALL-113594] 2OG [mitochondrial matrix] [SimpleEntity:R-ALL-113553] L-Asp [mitochondrial matrix]
precedingEvent	[Reaction:R-CEL-372448] SLC25A12,13 exchange L-Glu and L-Asp - Caenorhabditis elegans [Reaction:R-CEL-70501] PC carboxylates PYR to OA - Caenorhabditis elegans [Reaction:R-CEL-70979] MDH2 dimer dehydrogenates MAL - Caenorhabditis elegans [Reaction:R-CEL-8875623] SLC25A18,22 import L-Glu, H+ - Caenorhabditis elegans [Reaction:R-CEL-70609] glutamine + H2O => glutamate + NH4+ (GLS) - Caenorhabditis elegans
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:68320] Caenorhabditis elegans
stId	R-CEL-70613
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-CEL-9856872] Malate-aspartate shuttle [Pathway:R-CEL-8964539] Glutamate and glutamine metabolism
(precedingEvent)	[Reaction:R-CEL-376851] SLC25A11 exchanges 2-OG and MAL [Reaction:R-CEL-372448] SLC25A12,13 exchange L-Glu and L-Asp [Reaction:R-CEL-372480] 2-oxoglutarate [mitochondrial matrix] + 2-oxoadipate [cytosol] <=> 2-oxoglutarate [cytosol] + 2-oxoadipate [mitochondrial matrix]
(inferredTo)	[Reaction:R-HSA-70613] GOT2 transaminates OA and L-Glu